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However, you should seek urgent medical advice (via NHS 111 or an urgent treatment centre) if you experience: A fever above 39C Difficulty breathing Swelling of the face, lips or throat Widespread rash Severe dizziness or fainting Rapid or irregular heartbeat Serious reactions are rare, but prompt assessment is essential if concerning symptoms occur

They prevent the breakdown of NO-derived cGMP in vascular smooth muscle cells by competing with cGMP for the PDE5 catalytic site

Available from: Bowen RA, Dowdell KC, Dale JK, Drake SK, Fleisher TA, Hortin GL, Remaley AT, Nexo E, Rao VK